The #1 Gastroenterologist-Recommended

Serious Gut Issues Or Everyday Wellness?

Whatever your need, our potent probiotics are scientifically formulated to support your digestive well-being:

VSL#3® is a probiotic medical food intended for the dietary management of IBS, UC and pouchitis. Formulated to help you Have a Good Gut Feeling™ by supporting regularity, digestion and general gut health.*

Shop Now

VSL#3

We Are Pros In Probiotics

We've been making powerful, multi-strain probiotics for over twenty years, and our products are available in over 40 countries. Our experience has helped us gain the expertise needed to provide you with the right gut health solutions. Learn more about what makes our products special.

VSL#3

Potency, Guaranteed

VSL#3® offers some of the highest-potency probiotics available, ranging from 112.5 billion to 900 billion CFU per serving.

While some probiotic brands quote their potency based on the bacteria present at the date of manufacture, we quote the CFU count of our products at expiration if stored under recommended conditions. This means you get more of what you pay for.

Caption

The Importance of CFU Survival

For probiotics to be effective they need to reach the intestines in sufficient quantities. Once there, they can adhere to the intestinal walls to colonize and interact effectively with your microbiota. This interaction allows them to compete with bad bacteria for adhesion sites and nutrients, produce antimicrobial substances, and modulate the immune system by enhancing gut barrier function and reducing inflammation.
We use a “cold chain” supply chain, which is a temperature-controlled supply chain comprising refrigerated production, storage, and distribution facilities. We then ship VSL#3® to you in thermally lined, refrigerated shipping boxes. These measures ensure that our bacteria arrive alive and ready to colonize your gut.
VSL#3® is formulated to survive the harsh conditions of the gastrointestinal (GI) tract. In fact, it has been shown to have a 99% survivability rate after 120 minutes in a model of synthetic stomach acid - significantly higher than many of the other products tested1.

VSL#3

The Importance of Research

Research helps identify and verify the specific health benefits associated with different probiotic strains and formulations, to help ensure that consumers receive products that are both safe and effective. 

We are committed to helping the scientific and medical communities better understand the effects of probiotics on the microbiota and overall health. VSL#3® has been the subject of more than 40 scientific publications in the last five years alone. Researchers turn to VSL#3® because of its potency, eight-strain diversity, refrigerated bacteria, and overall quality. 

Us vs Them

High-potency probiotic medical food capsules scientifically formulated for the dietary management of IBS and ulcerative colitis.

  Visbiome®**

CFU per serving (billions)112.9-900

# of strains

Refrigerated

Medical Food

Dairy Free

The #1 Gastroenterologist-Recommended Multi-Strain Probiotics Brand†

#1 GASTROENTEROLOGIST-RECOMMENDED:

Trusted by experts, VSL#3 stands out as the #1 gastroenterologist-recommended multi-strain probiotics brand, and is designed for gut health in both women and men.
HIGH-POTENCY RELIEF: Each capsule of VSL#3 delivers 112.5 billion CFU of live probiotics, significantly more than most other leading brands. Now available as a 4 pack.
EIGHT-STRAIN BENEFITS: Scientifically formulated with 8 complementary probiotic strains from 3 different genera, VSL#3 is designed to restore balance and support issues like bloating and irregularity associated with serious gut conditions.

Buy Now

VSL#3 vs. Other Probiotics: What Makes It Unique

All formulations are free from common triggers like lactose, soy, nuts, and gluten. This matters because many people with digestive issues are sensitive to these ingredients. The products require refrigeration to maintain their proven viability - studies show the bacteria remain active even after exposure to stomach acid.

Nut-Free

Vegan

Dairy-Free

Gluten-Free

Non-GMO

Soy-Free

VSL#3

Using Probiotics for Ulcerative colitis

Reduces inflammation naturally: Probiotics encourage your gut to produce beneficial substances, like short-chain fatty acids, that help keep inflammation in check without the harsher side effects of certain UC medications. They can also help soothe symptoms such as gas, bloating, and constipation.

VSL#3

Potentially reduces the need for stronger meds

For some people, using probiotics regularly may decrease reliance on medications like steroids or immune suppressants, which often have unwanted side effects (like eye issues, bone weakening, or infections). Of course, always discuss medication adjustments with your healthcare provider.

VSL#3

Safe and gentle

Probiotics for UC are usually well-tolerated and have fewer risks compared to many traditional treatments. Side effects are generally minimal, making them an approachable option for long-term gut support.

Shop Now

VSL#3® Probiotics Capsules

check_box

How to Use

Instructions: VSL#3® capsules can be consumed with a cold, non-carbonated beverage. However, they should not be consumed with hot beverages or foods, as high heat inactivates the live bacteria in them.

Dosage: Take as directed by your physician (usual adult dosage is 2 capsules as needed, up to 4 times a day).

As a medical food, VSL#3® is intended to be used under medical supervision.

check_box

Ingredients

Strains:

Streptococcus thermophilus 
Bifidobacterium breve 
Bifidobacterium lactis 
(previously classified as B. longum)
Bifidobacterium lactis 
(previously classified as B. infantis)
Lactobacillus acidophilus
Lactobacillus plantarum
Lactobacillus paracasei
Lactobacillus helveticus 
(previously classified as L. delbrueckii subsp. bulgaricus)

Other Ingredients:

Vegetal capsule (hydroxypropyl methylcellulose), cornstarch, magnesium stearate, silicon dioxide, stearic acid, microcrystalline cellulose

check_box

Shipping

We ship our products to the continental US, Hawaii, and Alaska. Free shipping on capsule multipacks, powders, or any order over $101 (only applies to the continental US for VSL#3®). VSL4™ Gut and VSL#3® ship separately.

VSL#3®:

Our shipping schedule for VSL#3® products is optimized to reduce the time your temperature-controlled package is in transit. To this end, we generally ship VSL#3® Monday through Thursday morning, and shipping for most orders typically takes 1-2 days, depending on your location. VSL#3® does deliver on Saturdays.


For more information, please see our Shipping Policy.

check_box

Do VSL®products contain milk or dairy?

VSL®products are milk-free and dairy-free!

check_box

How should l store my VSL® products?

How should l store my VSL®products?

check_box

What is your return policy?

We cannot accept returns of our products as they cannot be reused or resold once they leave our facility; however, we do provide refunds in specific situations. Please see ourrefund and return policyfor more information.